New cosmetic ingredient "HyaluGuard" launched

Published: 3-Apr-2023

ICHIMARU PHARCOS has launched a new cosmetic ingredient, HyaluGuard, that inhibits HYBID for less sagging and youthful skin

Hyaluronic acid (HA) is one of the well-known skin components as a moisturizing factor. It is also known as relating to skin softness, resilience and viscosity. But how about the relation with the strength of ECM structure?

Dermal HA which holds lots of water helps maintain extracellular matrix structure effectively. Past study shows that a small amount of skin HA is correlated with skin sagging index and wrinkle depth. Unfortunately, The amount of HA decreases with aging. It is known that HA loss is caused by hyaluronidase HYAL1/2. But recent studies revealed, in the dermis, HA is mainly degraded by HYBID, the novel HA cleavage enzyme. The expression level of HYBID is correlated with skin sagging and wrinkle.

ICHIMARU PHARCOS searched for a material that inhibits the expression of HYBID in fibroblasts and found that an extract of Artemisia capillaris flowers had this effect, and launched the natural cosmetic ingredient “HyaluGuard”. HyaluGuard inhibits the degradation of HA in fibroblasts and works to reduce skin sagging and wrinkle.

Launched March 28th, 2023 - Learn more here

Effects of HyaluGuard

  • Protection of HA from degradation
  • Reduction of skin sagging
  • Reduction of skin wrinkle
  • Increase of moisture content


  • COSMOS APPROVED certificated (in progress)
  • IECIC2021 Listed

Exhibition Guide

  • in-cosmetics grobal 2023

Relevant companies

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