Vegan PDRNs are set to be more popular than salmon sperm. Here’s why…

By Lollie Hancock | Published: 16-Feb-2026

As skin care brands increasingly seek out vegan alternatives to marine-derived PDRN, Cosmetics Business explores how these alternatives are set to become a mainstay in skin care

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We have all heard of the ‘salmon sperm’ facial – the skin treatment that sees the DNA fragment purified and administered into the skin through injections or microneedling – loved by the likes of actress Jennifer Aniston and Skims founder Kim Kardashian.

As with most advanced treatments, the wonder ingredient known for its repairing properties has found its way into at-home skin care in recent years through serums and creams.

However, new innovations mean a number of vegan alternatives to polydeoxyribonucleotides (better known as PDRN) are now making their way to the market, shaking things up.

The plant-based topical treatments are beneficial for a number of skin concerns – most known for its skin regeneration properties, as well as collagen stimulation, tissue repair and anti-inflammatory properties – as well as offering an ethical alternative to the ingredient.

“PDRN is a regenerative DNA complex that stimulates skin repair at a cellular level,” says Kimberley Medd, Head of Clinic at skin care and beauty specialist Face The Future

“You will have seen this everywhere recently as it is making waves on social media, through Korean skin care and masks. 

“Clinically, it reduces inflammation, activates fibroblasts and supports collagen production. 

“In practice, we use it to accelerate healing, strengthen the dermis, and improve elasticity, particularly after aesthetic procedures or in compromised, ageing skin.”

Melody Yuan, founder of specialist Korean skin care beauty retailer Skin Cupid, explains: “PDRN is more than a trendy ingredient; it is the future of skin care. 

“PDRN represents a fundamentally different way to think about treating our skin.

“Instead of seeking to treat skin troubles as quickly as possible with harsh acids or covering imperfections, PDRN helps the skin repair itself and build resilience over time. 

“That is why it has been such an important part of Korean beauty innovation, and why it is beginning to gain traction more widely.”

What are the vegan alternatives to PDRN – and how do they stack up against salmon sperm?

Now, a number of brands are incorporating vegan alternatives to the marine-derived ingredient.

Medd explains: “Plant-based ingredients such as ginseng and algae offer anti-inflammatory and antioxidant benefits that support hydration, barrier repair and overall skin quality. 

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