Ashland targets skin longevity with mitochondria-inspired innovation

Published: 1-Jun-2026

Eternight biofunctional is an iris root extract designed to address longevity through a [3R] framework - Rest, Restore, Reverse - by targeting mitochondrial biology via Ashland’s Mitobiology concept

 
Recent advances in longevity science position mitochondria not only as energy producers, but as dynamic signaling networks involved in cellular resilience and aging. Among key mediators, humanin—a mitochondria-derived peptide—has been associated with healthy aging and is reported at higher levels in centenarian populations.
 
Acting as a cellular messenger, it is suggested to coordinate stress response and repair mechanisms.

Eternight™ biofunctional leverages this biology to support nocturnal skin recovery, when endogenous repair pathways are most active. The [3R] approach integrates:

  • Rest, by supporting skin during its night-time regenerative phase
  • Restore, inspired by mitochondrial quality control processes such as mitophagy and fusion
  • Reverse, contributing to the reduction of visible signs of aging over time

This approach is referred to as “mitorestoration,” focusing on maintaining mitochondrial health and leading to a better control of cellular senescence.

The active is derived from Iris pallida rhizome, cultivated in France through regenerative agriculture and processed after a long maturation cycle. The extract is valorized through AI-driven analysis and Ashland’s patented PSR™ (Plant Small RNA) technology, enabling a unique molecular profile.

Clinically evaluated on different skin types, eternight™ biofunctional helps to revive multiple visible signs of youth, aligning with increasing demand for night care routines and longevity-oriented cosmetic approaches.

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