An anti-inflammaging solution to counteract skin redness and signs of ageing

Published: 10-May-2023

CALMandrin™ is Mibelle's sustainable solution for combatting inflammaging by notably improving the signs of ageing, as well as soothing reddened and inflamed skin

In addition to its calming effect on irritated skin, it also markedly increases the firmness and density of the skin. CALMandrin™ is obtained by upcycling the peel paste of organic mandarins used in the distillation process of organic fragrance production. These unique mandarins are grown exclusively in very specific conditions in the beautiful, historic orchards of the Greek island of Chios.

In vitro and in vivo studies have demonstrated that CALMandrin™

  • inhibits the activation of NF-κB, a key regulator of inflammation
  • reduces the expression of genes linked to the inflammatory response
  • counteracts inflammation-induced protein damage that is associated with ageing
  • increases the production of young collagen and improves dermal skin density
  • visibly calms reddened and irritated skin
  • provides more skin elasticity and firmness
  • delivers a remarkable, rapid anti-aging effect, as well as an anti-redness effect after just one week.

CALMandrin™ counteracts the inflammatory immune response that results from both chronic ageing and extrinsic stress to defeat inflammaging. CALMandrin™ is COSMOS approved* and NATRUE approved.


  • Calms irritated skin
  • Soothes inflamed and reddened skin
  • Promotes collagen production
  • Improves skin firmness and skin density


  • Anti-ageing treatments
  • Calming gel masks
  • Anti-inflammaging skin care
  • Collagen boosting serums

Formulating with CALMandrin™

  • Recommended use level: 1 – 3 %
  • Incorporation: CALMandrin™ can be incorporated into most formulations, emulsions, and gels, except water-free formulations. For cold processes, dissolve CALMandrin™ into the aqueous phase or add it after emulsification. For hot / cold processes, add during the cooling phase below 40 °C.
  • Thermostability: Temperatures of up to 40 °C do not affect the stability of CALMandrin™.

INCI (EU / PCPC) Declaration

Citrus Reticulata Extract / Citrus Reticulata (Tangerine) Extract (and) Glycerin (and) Pentylene Glycol (and) Aqua / Water

Additional Information

  • Organic source
  • Water-soluble
  • Without preservatives
  • Without alcohol

Click here to learn more about CALMandrin™

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