Skin care is evolving in an increasingly holistic and fundamental manner. As the need for more fundamental skin improvement grows beyond caring for skin troubles or dead skin cells that are visible on the outside, treatments using exosomes, especially in aesthetics, are gaining attention, and cosmetics containing exosome ingredients are being released.
The vitality of the plant can be felt in the buds that are preparing to sprout leaves in the still cold winter. Plants' natural defense ability against biotic or abiotic stress has been applied to skin and hair care in various forms and methods since a long time ago. Exosome technology and various products using it are emerging as a way to more effectively deliver the vitality and unique efficacy of plants to the skin. Exosomes are naturally occurring nano-sized (50-150 nm) endoplasmic reticulum released by cells. They contain complex bioactive substances and information and are known to function as messengers for tissue repair, immune system regulation, and information transfer between cells.
Exosomes have the advantage of being able to be stored for a long time due to their long persistence of up to one year, being stable between -70 and 60 degrees, making them easy to store, and having a low possibility of side effects due to their high biocompatibility. In particular, plant-derived exosomes
are evaluated to have high industrial utility value due to their safety, absorption capacity, effectiveness, and active ingredient content compared to plant extracts or liposomes, and the market size is expected to expand rapidly.
ActivEXO-MF, platform technologies for plant-derived exosome
ActivEXO-MF is a plant-derived exosome processing technology owned by ACTIVON. While the existing plant-derived exosome purification method is separation and purification through centrifugation, ActivEXO-MF is characterized by separation and purification using functionalized beads and microfluidic chips. ActivEXO-MF is a technology that enables mass production of stabilized plant-derived exosomes, improving on the problems of existing methods, such as long purification time due to complex separation method, inability to selectively separate exosomes, differences in purification efficiency between batches, and concerns about contamination during the centrifugation process. ACTIVON has applied for a patent on the extraction and separation method of plant-derived exosomes, the exosomes isolated accordingly, and their cosmetic uses. Acxosome™ series-Exosomes derived from plants and lactobacillus
1. Acxosome™ CICA
Origin | Centella asiatica (Gotu Kola)
INCI | Centella Asiatica Leaf Vesicles
Efficacy | Wound healing, Anti-aging, Anti-inflammation, Skin hydration
Benefits | COSMOS / Vegan Certificated
2. Acxosome™ Licorice
Origin | Licorice root (Glycyrrhiza Uralensis root)
INCI | Glycyrrhiza Uralensis (Licorice) Root Extracellular Vesicles
Efficacy | Skin whitening, Anti-wrinkle
Benefits | COSMOS / Vegan Certificated
3. Acxosome™ Paeonia
Origin | Paeonia Lactiflora , Peony
INCI | Paeonia Lactiflora Root Vesicles
Efficacy | Anti-aging, Anti-inflammation, Anti-oxidant
Benefits | COSMOS / Vegan Certificated
4. Acxosome™ LactoR
Origin | Lactobacillus reuteri (GRAS, food grade)
INCI | Lactobacillus Extracellular Vesicles
Efficacy | Wound healing / Cell proliferation, Anti-inflammation
Benefits | COSMOS / Vegan Certificated
