PromaCare NAA is a supramolecular eutectic compound formed by niacinamide and azelaic acid through hydrogen bonds, van der Waals forces and other non-covalent interactions, creating a stable and ordered crystal structure. Developed with supramolecular cocrystal enhancing technology, this structured combination integrates the complementary properties of both actives within a single material system. This crystal-driven design effectively improves the water solubility and formulation compatibility of azelaic acid, while enhancing the fat solubility and stability of niacinamide under over-acid conditions.
By structuring the two ingredients at the supramolecular level, PromaCare NAA enables their synergistic performance, providing gentle skin brightening, mild exfoliation, antioxidant activity and anti-inflammatory benefits. It is suitable for both leave-on and rinse-off formulations and is designed to address multiple concerns associated with oily, acne-prone and sensitive skin, including uneven skin tone, visible pores, acne marks and redness.
Efficacy studies demonstrate a clear breakthrough in whitening and spot reduction. After 28 days of continuous use of an essence containing 3% PromaCare NAA, skin whiteness increased by 21.39%, while visible spots faded significantly. Anti-inflammatory evaluation showed that 0.00313% PromaCare NAA inhibited IL-1α, TNF-α, IL-8 and PGE2 by 41.11%, 61.67%, 63.78% and 42.23%, respectively. In comparison, 0.1% niacinamide inhibited IL-1α, TNF-α and PGE2 by 34.71%, 16.57% and 28.57%, with no inhibition observed for IL-8, confirming the superior soothing and anti-inflammatory performance of PromaCare NAA.
Thanks to its unique crystal structure, PromaCare NAA overcomes the heavy or gritty skin feel often associated with conventional actives limited by solubility, delivering a refreshing and pleasant sensory profile. This makes it an ideal choice for the development of high-end antioxidant, brightening and soothing product lines that combine mild efficacy with an elevated user experience.
