Are you afraid of the sun? JAKA has the solution

Published: 31-May-2023

Solarepare MB is a natural and new active ingredient for UVB damage repair and defence. It is extracted from the Magnolia bindii flower, rich in lignans. Targeting “damage-associated molecular patterns” (DAMPs) can reduce sunburned cells, inhibit the migration of HMGB1 from the nucleus and relieve vascular activation caused by UVB

Clinically, it can protect the skin after sun exposure and alleviate skin erythema. It’s natural and COSMOS-approved.

It can be used in soothing and repairing skincare products. It also can be used as an effective booster in sunscreen products. Suitable formulations include sunscreen, spray, gel, essence, emulsion, etc.

Nowadays, more and more consumers consider sunscreen and suncare products inevitable. They are looking for new suncare products that not only have essential sunscreen functions but also with repairing and nourishing effect. Moreover, they pay more attention to natural and green products.

Following this trend, we develop a new type of active ingredient for sun care, Solarepare MB. It is mainly for UVB protection and repair, specifically, redness after sunburn.

The UVB exposure will cause DNA damage to the cells on the skin. The cells will secrete DAMPS (Damage associated molecular patterns). And then DAMPS will cause more cells damage in the deeper layers and finally induce inflammation and redness on the skin.

Among the DAMPs system, there is a critical member called HMGB1. It’s also known as High-Mobility Group Box 1 protein. In normal or healthy conditions, HMGB1 is located in the nucleus, which functions positively in DNA repair. However, when cells are damaged, a large amount of HMGB1 are released and migrated from the nucleus which will induce inflammation. Therefore, we need to inhibit HMGB1 migration from the nucleus to deal with sunburn, redness and inflammation.

Solarepare MB targets HMGB1 which is an innovative mechanism among suncare products. It shows that 0.02-2% Solarepare MB can inhibit HMGB1 migrating from the nucleus to relieve the sunburn cells. At the same time, it can protect the cells from DNA damage (decrease 8-OHG and CPD, both are DNA damage markers) and increase cell viability.

Ex-vivo test

Are you afraid of the sun? JAKA has the solution

In the clinical test, it shows that 0.5-2% Solarepare MB can reduce and repair the redness on the arms after UVB exposure (Photo analysed by VISIA).

In Vivo Test

Are you afraid of the sun? JAKA has the solution

Solarepare MB is extracted from Magnolia biondii flower from its original growing area. This plant grows flowers before leaves. It takes 7-8 years from planting to flower budding. The flower is rich in lignans.

The lignans are a large group of low molecular weight polyphenols  found in plants, which have good anti-inflammatory and anti-oxidant effects.

In conclusion, Solarepare MB is a new type of active ingredient for suncare products. Different from other synthetic or inorganic sunscreen ingredient, it is natural and COSMOS approved. It meets the new demand of consumers for suncare products. It has innovative mechanism which is to target at HMGB1.

It can be used together with other sunscreen ingredients, providing greener sunscreen effect; it can also be used in daily skincare product to provide consumers comprehensive protection from daily sunlight exposure.

Are you afraid of the sun? JAKA has the solution





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