Cosmebiome: Innovative Clinical Study
The recently published dermatologist-supervised open-label clinical study investigated the effects of Cerebiome® on 35 healthy caucasian women aged 30-45 over an 8-week period. Participants took 3 billion CFU of Cerebiome® once daily 1 .
Significant Reduction in Perceived Stress
The primary outcome measured perceived stress using the PSS-10 at Days 28 and 56. The study found a significant reduction in perceived stress, with an 18% decrease after 4 weeks and a 31% decrease after 8 weeks. Additionally, 79% of participants reported noticeable improvements in their mental well-being.
Figure 1 : Perceived Stress Score Evaluation
Benefits for Sleep
Secondary outcomes from the study revealed significant improvements in sleep quality. Participants experienced a notable enhancement in their ability to fall asleep and stay asleep, along with a reduction in difficulties staying awake during the day.
Benefits on Skin Appearance
In terms of skin appearance, Cerebiome® has shown to contribute to skin hydration, firmness, and the reduced appearance of wrinkles, fine lines, and skin tone. There was a significant increase in skin hydration, with a 21% improvement on the face after 8 weeks and up to 18% improvement on the body. Additionally, 85% of women reported feeling their skin was more hydrated and moisturised.
The study also showed significant improvements in skin tone, firmness, and elasticity, with a 12% increase in skin firmness after 8 weeks of Cerebiome® intake. The Cosmebiome study also highlighted significant improvements in the reduced appearance of wrinkles and fine lines. After just 4 weeks of Cerebiome® intake, participants saw a 7% reduction in the appearance of facial wrinkles, which increased to 17% after 8 weeks. The forehead area showed even more pronounced results, with a 12% reduction after 4 weeks and a 21% reduction after 8 weeks. Additionally, 82% of women reported that their skin felt smoother and had an improved texture, demonstrating the powerful impact of Cerebiome® on enhancing skin appearance, texture, and overall complexion.
Figure 2: % skin change at day 28 and day 56 compared to baseline
These findings underscore the comprehensive benefits of Cerebiome® for both holistic mental well-being and skin health.
Elodie Aragon, Product Manager at Lallemand Health Solutions details the potential impact of the study for the nutricosmetics market: “Cerebiome® is already a well-known, easy-to-formulate psychobiotic in the supplement market, with many commercial successes worldwide. With this innovative, one-of-a-kind proof-of-concept study, we offer opportunities for our customers to have solutions for the booming nutricosmetics market. This new study enables our customers to make beauty claims with this combination of two probiotic strains.”
Applications and methods of use*
The formula is available in various dosage formats including soluble powders, orodispersible powders, capsules, sticks, sachets and more. It can be formulated with ingredients like riboflavin (vitamin B2) and folic acid (vitamin B9) for skin stress and anti-aging, vitamin B6 for stress/mood and skin balance, melatonin and vitamin B6 for sleep and skin balance, and vitamin C and copper for energy and bright skin. Cerebiome® and other documented strains can support beauty claims in Europe. From lab to shelf, Lallemand Health Solutions has the full control and expertise to produce premium tailored-made probiotic formulations in state-of-the-art facilities
certified for the highest quality.
* Formulas claim based on strains scientific data and according to local regulation
Reference
[1] Kassem, O., Tremblay, A., Ghaly, M. S. W., Oula, M.-L., Bronner, S., & Binda, S. (2025). A subjective evaluation of the effects of a probiotic formulation on skin quality in young adult females: Open-label proof-of-concept study. International Journal of Probiotics and Prebiotics, 20(1), 1–9. https://doi.org/10.37290/ijpp2641-7197.20:1-9