Silab is promising effective skin depigmentation and complexion unification for caucasian and Asian skin from Whitonyl, its new skin lightening ingredient rich in xylose and galactose from Palmaria palmate, a red alga.
The ingredient is said to limit melanogenesis, limit the transport of melanosomes and control photo-induced pigmentation, leading to significant lightening of senescence and brown spots due to sunlight.
Tested at 2% Whitonyl was found to reduce the activity of tyrosinase by 27% and inhibit melanin synthesis by 52%. Again tested at 2% by Western blot and immunocytology, the material was said to significantly reduce syntheses of Rab27a (-31%) and melanophilin (-35%), the protein anchoring complex involved in the transport of melanosomes. Tested at 1% using the Elisa assay, Whitonyl was said to significantly reduce the activity of the stem cell factor (SCF) that increases following UVB irradiation; an 81% decrease of SCF was recorded, limiting photo-induced pigmentation.
In subjective evaluation conducted on 25 healthy volunteers, after eight weeks of twice daily applications volunteers reported more effective depigmentation than a placebo. Instrumental evaluation analysing photos of before and after treatment on Asian skin showed depigmentation after 56 days of twice daily applications , an effect observable in 68% of volunteers.