Authors: Ingrid Johanna Rojas G, M.Sc., Fabiola Echegaray M.Sc., Sonia Mayorga, Belcorp, Innovation and Research Laboratories, Cundinamarca, Colombia
This study was performed to determine which of the preservative systems used in the formulation of body and facial creams is the most effective for the elimination of microbial contamination using the preservative challenge test and analysis by linear regression. These tests obtain results faster than CTFA and USP methods. For the microorganisms tested, S.aureus is the most difficult to eliminate by preservatives and P.aeruginosa is the most sensitive to the antimicrobial action of preservatives. To eliminate moulds and yeasts, the preservative system with Isothiazolinones and hydantoin is the most effective; however each formulator should be able to find the best combination of preservatives that can eliminate all kinds of microorganisms. Tests showed that parabens are the components that most effectively eliminate microbial contamination of products during use; however it is necessary to test new types of preservatives which are not considered to be a risk to human health.
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