Xymelys 45 reduces inflammaging: A new way to prevent skin ageing

Authors: Rachida Nachat-Kappes Ph.D, Magali Favre-Mercuret, Magalie Cabannes, Laurent Rios Ph.D., Edwige Ranouille Pharm.D., Virgile Duclos, Elodie Fessy, Véronique Jay-Debaut Ph.D., Dojeanny Leng Pharm.D, Jean-Yves Berthon Ph.D., Greentech SA, Saint Beauzire, France

The skin as an external organ has to face many aggressions, including mechanical stress, microbial attacks, UV radiation and exposure to allergens, chemicals, detergents or smoke. These countless assaults can induce acute inflammatory responses. This visible form of inflammation (pain, heat, redness, swelling) is required for skin repair and is characterised by rapid onset and is generally short lived. However, when the skin is subjected to excessive, prolonged or uncontrolled inflammation, this leads to a state of low-grade chronic inflammation. This kind of inflammation that remains silent is usually invisible and symptom-free. Additionally, it occurs over longer times and has been clearly linked to biological ageing process and in promoting premature skin ageing. This phenomenon named ‘Inflammaging’ is characterised by a significant increase of pro-inflammatory mediators and oxidative stress.

In fact, under normal conditions, the cellular redox balance is tightly regulated by several antioxidant defence systems (enzymes, vitamins etc.). However, in the case of chronic inflammation, the antioxidant defences are insufficient. Consequently, the accumulation of reactive oxygen species (ROS) results in oxidative stress that is deleterious to the cell and accelerates the ageing process.

Thus, the prevention and/or reversal of ‘inflammaging’ are based on the development of innovative strategies that simultaneously targets inflammatory mediators and oxidative stress.

Therefore, Xymelys 45, a powerful anti-inflammatory and antioxidant active has been developed to target the major contributors of ‘inflammaging’. Indeed, Xymelys 45, strongly inhibited two key pro-inflammatory enzymes, the cyclooxygenase-2 (COX-2), involved in the production of prostaglandin E2 (PGE2) and the 5-lipooxygenase (5-LOX), responsible for the synthesis of leukotriene B4 (LTB4). Additionally, the antioxidant ability of Xymelys 45, demonstrated with the FRAP assay, was four fold higher that an acai extract, well known for its antioxidant properties.

Thanks to its dual actions, Xymelys 45 fights against ‘inflammaging’ and is an innovative way to preserve the youth of the skin.