Combining a topical anti-ageing ingredient with a nutricosmetic mixture can more effectively target skin problems, improving skin condition from both the inside and outside as Marta Rull, Cristina Davi, Elena Cañadas, Juan Cebrián and Raquel Delgado explain
Recent reports indicate that the global population aged over 60 will more than double by 2050 and the number of people aged 40-50 will rise extraordinarily as well.[1] In tandem with this we can assume that the needs and desires of the mature population will also continue to increase, including the desire to minimise wrinkles, get rid of spots and reduce sagging, elastosis and flaccidity, all of which affect self-esteem. We can also assume that consumers will want to use effective but non-aggressive anti-ageing treatments to address these issues.[2]
Daily UV exposure and natural ageing generate negative cellular effects such as the formation of free radicals and reactive species, alteration of the extracellular matrix (ECM), degradation of the connective tissue, DNA damage and the rise of matrix metalloproteinases (MMPs). These MMPs contribute to skin firmness and elasticity loss because they degrade collagen and elastin, which are essential proteins for both skin properties. Collagen is the skin’s most abundant protein, playing a key role in its mechanical and structural integrity.[3]
Eighty percent of dermal collagen is type I, which assembles into collagen fibrils and polymerises into larger collagen fibres.[4] Skin strength and resistance depend on the diameter of these fibres, as they are weaker when the diameters are smaller.[3,5,6] Unfortunately, collagen synthesis decreases when ageing (accompanied by increased degradation and fibril network disorganisation) and this facilitates wrinkle formation and loss of the skin’s 3D integrity.
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