How mitophagy detoxifies and energises the skin for a visible anti-ageing effect


This is a story about the peony and how we have unveiled its beauty secret

Mitochondrial ageing is one of the causative factors of cell ageing. Mitochondria, responsible for generating the energy needed by the cell, age over time and become less effective.

According to the discoveries made by Yoshinori Ohsumi, for which he was awarded the Nobel Prize for Medicine in 2016, autophagy mechanisms are responsible for discarding the worn out cellular material. When mitochondria are no longer functional, the cell has a system to degrade and recycle them selectively, mitophagy, which functions as quality control.

These cell renewal systems deteriorate with age and so, over time, cells tend to accumulate mitochondria that do not function optimally.

If mitophagy is stimulated, the cell will slough off these dysfunctional mitochondria and be able to work at full capacity. For this reason, mitophagy, is considered one of the most powerful ways to rejuvenate cells.

Detoskin reduces the reactive oxygen species in the skin

Detoskin is a combination of trehalose and paeoniflorin intended to promote mitophagy and skin detoxification. Trehalose is a natural disaccharide derived from starch, through a bioprocess accepted by COSMOS. Paeoniflorin is obtained from a root fraction of Paeonia lactiflora, the peony, queen of flowers.

Peony is an emblem of health, beauty and femininity. Owing to its attractive, curvy appearance and its fragrance, it is one of the main flowers chosen to decorate gardens and a prime contender to form part of the bride's bouquet at wedding celebrations, as a symbol of lasting love.

The efficacy of Detoskin in vivo was assayed with a panel of 32 women, from 40 to 60 years of age, presenting facial signs of ageing skin.

One of the consequences of mitochondria malfunctioning is an increase in the amount of ROS, which act as toxins, accelerating ageing even further.

Detoskin reduced the ROS in the skin by up to 64% on day 56.

Energising the cell by improving the mitochondrial pool shows results in all levels, and the outer appearance of the skin also improves, the anisotropy affected by ageing is reduced and the skin shows a more uniform and smooth tone and enhanced elasticity.

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Wrinkles also show an improvement when mitophagy is activated, and show the holistic anti-ageing effect when the powerhouse of the cell works to its fullest potential.

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