The search for effective solutions to visible signs of hair aging has gained a new scientific ally. While a large portion of the global hair care market still focuses on masking gray hair using synthetic pigments, Chemyunion introduces an innovative biotechnology-based approach: BioTech4 AntiGray (INCI: Lactobacillus Ferment Lysate).
Developed through a proprietary platform, this postbiotic ingredient acts directly on the biological mechanisms responsible for hair graying. Rather than simply concealing gray strands, its approach is to stimulate the natural resumption of melanin production within the hair follicle, progressively restoring the functionality of the hair pigmentation system.
The appearance of gray hair is one of the most evident signs of hair aging and is associated with the progressive decline in melanocyte activity within the hair bulb, often exacerbated by oxidative stress. This process impairs both the synthesis and transfer of melanin to the hair fiber, leading to a gradual loss of natural hair color.
Within this context, BioTech4 AntiGray acts as a biological signaling agent, promoting an integrated approach that:
- Stimulates melanogenesis: Reactivates melanocyte activity in the hair follicle, supporting the resumption of melanin production
- Supports pigmentary cells: Contributes to the maintenance of melanocyte stem cells and the functionality of the hair pigmentation system
- Protects against oxidative stress: Stimulates antioxidant gene expression to preserve melanocyte cell integrity
- Meets clean beauty trends: With 98.7% natural origin content, it aligns with the growing demand for sustainable and biotech-driven solutions
Scientific Evidence and Proven Results
The efficacy of BioTech4 AntiGray has been demonstrated through both ex vivo and in vivo studies, confirming its potential for application in hair care formulations targeting the prevention and reversal of hair graying.
In an ex vivo model using human hair follicles from a 50-year-old male donor, a 43% increase in melanin content in the hair bulb was observed, confirming the ingredient’s ability to stimulate pigmentary activity directly at the root level.

Complementing these preclinical findings, an in vivo study conducted with 90 volunteers (men and women aged 20–55) over 120 days, using a formulation containing 3% of the active, demonstrated significant results:

Among the main observed outcomes:
- 76.7% of participants reported a visible reduction in gray hair
- 27% increase in hair color uniformity
- Noticeable reduction in the intensity of white/gray strands
- 90% overall satisfaction after using formulations containing BioTech4 AntiGray
These findings indicate that modulating the biological mechanisms of pigmentation can contribute to the gradual recovery of natural hair color.
Potential for Innovative Formulations
With high technological versatility, BioTech4 AntiGray can be incorporated into a wide range of hair care products, including tonics and treatment shampoos, enabling the development of advanced solutions focused on hair longevity and the preservation of natural color.
By acting directly at the biological origin of the graying process, the ingredient enables a new generation of hair care products that go beyond camouflage, delivering functional care to the hair pigmentation system.