Sytheon is excited to share that Synastol® TC is now available as a nutritional supplement – the first standardised Terminalia Chebula Fruit Extract for this application in the industry.
Terminalia chebula is an edible superfruit that’s known for its use in ayurvedic as a dietary supplement to treat a wide range of health conditions, including diabetes and arthritis. In skin care, Synastol® TC is a natural and well-defined extract of Terminalia chebula. When used in topical applications, Synastol® TC is clinically proven to improve the appearance of wrinkles, repair skin barrier dysfunction, and reduce the negative effects of pollution and blue light-induced skin damage.
As an innovative, research-backed company, Sytheon is always looking for new ways to use proven ingredients to positively impact personal care. Sytheon saw the opportunity to take the beneficial, holistic characteristics of TC to the next level by developing an ultra-concentrated and standardised bioactive powder form that can be used as an oral supplement. Synastol® TC delivered in a hard gelatin capsule promises exciting benefits for customers.
Improvement in Gut Homeostasis
Gut health plays an important role in overall well-being, including skin health. When used as an oral supplement, Synastol® TC is linked to improving gut health by elevating microbiome diversity.
In a double-blind, placebo-controlled, 8-week study, subjects took 250 mg capsules of Synastol® TC twice a day to evaluate the effect of oral TC on the gut microbiome and relevant biochemical pathways (results submitted for publication). The results were statistically significant:
- Greater alpha diversity and increased amounts of favourable gut bacteria and phages (p<0.05)
- Increase in Akkermansia muciniphila; Expected to become a new probiotic in addition to Lactobacillusand Bifidobacterium
- Increase in Short Chain Fatty Acid (SCFA, epigenetic regulators) production
- Increase in serum bile acids (effectors of gut microbiome) synthesis
- Increase in production of Acetic Acid (p=0.045)
- Increase in production of Propionic Acid (p=0.001)
- Increasing trend of Butyric Acid (p=0.12)
Beauty From The Inside Out
When used as an oral supplement, Synastol® TC successfully targets sebum excretion rate (linked to acne), facial erythema (redness), and wrinkles. In a double-blind, placebo-controlled, 8-week study, subjects took 250 mg capsules of Synastol® TC twice a day. The results showed:
- 33% decrease in sebum excretion rate after 8 weeks of Synastol® TC, compared to a 29% increase with placebo.
- Statistically significant decrease in cheek erythema after 8 weeks of Synastol® TC treatment, compared to an increase with placebo.
- Statistically significant decrease in wrinkles after 8 weeks of Synastol® TC treatment, compared to an increase with placebo.
Sytheon states: "Overall, our findings suggest that oral supplementation with standardised TC extract with a highly enriched hydrolyzable tannins has beneficial properties for the skin, which may be due to improved gut health."
