Sytheon announces a new publication on Atopic Dermatitis

Published: 7-Dec-2022

Sytheon is excited to announce a publication on synergistic anti-inflammatory effects of isosorbide fatty acid diesters in Cytokine-induced tissue culture models of Atopic Dermatitis

Atopic dermatitis (eczema) is a chronic condition that makes your skin red/ itchy, and flares occur periodically due to epidermal barrier disruption to the TH-2 mediated inflammation process. It is common in children but can occur at any age due to environmental impact. Topical emollients are a cornerstone of management of disease.

This study evaluated efficacy of two plant derived oil derivatives, isosorbide di-(linoleate/oleate) (HydraSynol IDL) and isosorbide dicaprylate (HydraSynol DOI), using AD-like tissue culture models. Treatment of reconstituted human epidermis with cytokines led to significant reduction in inflammatory and neurogenic pruritus mediators. These results demonstrated anti-inflammatory mechanisms of isosorbide fatty acid diesters in AD-like skin models. These findings highlight the multifunctional potential of HydraSynol IDL and DOI as therapeutic candidates to treat Atopic Dermatitis.

Current study complements an earlier study published by the company (J Investigative Dermatology, 2021, 141:1416-1427) on IDL which has shown to stimulate pro-differentiation gene expression to restore the epidermal barrier and improve skin hydration.

Swindell, W.R.; Bojanowski, K.; Chaudhuri, R.K. Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis. Int. J. Mol. Sci. 2022, 23, 14307.

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