Customised R&D services: Designing unique solutions for your R&D needs

AntalGenics is a biotechnological company with more than 15 years of experience in Sensory Neurobiology. Stimuli detection and integration by neurons make the cutaneous nervous system a fundamental target to treat diverse skin conditions. They are focused on the design and development of new molecules for cosmetic and pharmaceutical applications

Their customers are constantly supported by their team in every step of their projects through elaboration of innovative proposals, along project execution, with constant scientific advice and generation of novel intellectual property.

Their services include:

• Molecular design
• High-throughput screenings
• Ingredients validation
• Functional characterisation

Their in silico services platform allows innovation in the development of cosmetic, pharmaceutical and nutraceutical ingredients through:

• Design of new compounds
• Characterisation of the activity and claims of new ingredients (peptides and natural or synthetics molecules)
• Repositioning of existing ingredients re-targeting them
• Characterisation of physico-chemical and organoleptic properties
• Toxicity and bioavailability studies
• Prediction of molecule drug-like properties

They provide high-throughput screening services for several functional assays:

• Molecular Biology
• Immunological assays
• Cellular assays in primary sensory neuronal culture, neuron-like cells, and human cells

They are specialised on the functional study of receptors, ion channels, molecular targets, and protein-protein interactions implicated in cutaneous nervous system and skin physiology. They deepen into the characterisation of the mechanism of action of molecules through:

• Multimodal micro-plate reader and IonFlux for automatised electrophysiological characterisation of cells
• IN cell imaging in living cells to monitor cellular processes like exocytosis
• Cell lines, 2D and 3D skin models

They employ neuronal models to explore the efficacy of compounds in physiological or altered skin contexts. They use monitoring systems such as:

• Multi-electrode Array System to study compound’s effect over the excitability of neuronal populations
• Single cell patch clamp effect characterisation
• Neuropeptides or neurotransmitter release quantification
• Neurotoxicity and neuro-inflammation assays

WANT TO KNOW MORE? Contact info@antalgenics.com

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